Article

Berberine Ameliorates Primary Biliary Cholangitis by Modulating the Gut–Liver Axis and Attenuating Cholangiocyte Oxidative Stress in Murine Models and Human Organoids

2026-08-31

Abstract excerpt

<title>Abstract</title> <p>Background Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic liver disease characterized by progressive destruction of intrahepatic bile ducts, resulting in liver inflammation and fibrosis. Despite ursodeoxycholic acid as the standard therapy, a substantial proportion of patients show incomplete responses. Berberine hydrochloride (BBR), a bioactive alkaloid derived...

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Literature Corpus work: cec1d0df-151d-5c37-9e1a-b9130b38c2c5
DOI: 10.21203/rs.3.rs-10116628/v1

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Berberine Ameliorates Primary Biliary Cholangitis by Modulating the Gut–Liver Axis and Attenuating Cholangiocyte Oxidative Stress in Murine Models and Human OrganoidsDOI 10.21203/rs.3.rs-10116628/v1Read

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