Article

Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells

2023-08-07

Abstract excerpt

Hepatic stellate cells (HSCs) are activated with chronic liver injury and transdifferentiate into myofibroblasts, which produce excessive extracellular matrices that form the fibrotic scar. While the progression of fibrosis is understood to be the cause of end-stage liver disease, there are no approved therapies directed at interfering with the activity of HSC myofibroblasts. We performed a high-throughput small i...

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Literature Corpus work: d76ddcda-aac2-5a27-95cf-a812858baf1d
DOI: 10.1101/2023.08.07.551744

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