Article

MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles

2024-02-21

Abstract excerpt

<h4>Background & Aims</h4> The prevalence of metabolic dysfunction-associated steatohepatitis (MASH) is increasing, urging more research into the underlying mechanisms. MicroRNA-26b (miR-26b) might play a role in several MASH-related pathways. Therefore, we aimed to determine the role of miR-26b in MASH and its therapeutic potential using miR-26b mimic-loaded lipid nanoparticles (LNPs). <h4>Methods</h4> Apoe -/...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8e6942af-955d-5d66-9c50-71c413bb47f5
DOI: 10.1101/2024.02.18.580792

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticlesDOI 10.1101/2024.02.18.580792Read

MicroRNA-26b-/- augments atherosclerosis, while mimic-loaded nanoparticles reduce atherogenesis.Semantic proximity Read

Manipulating the Gut Microbiome to Alleviate Steatotic Liver Disease: Current Progress and ChallengesSemantic proximity Read

Myeloid cells contribute to bystander CD8 T cell accumulation in metabolic-associated steatohepatitis and are sufficient for fibrosisSemantic proximity Read

Gut dysbiosis-derived exosomes trigger hepatic steatosis by transiting HMGB1 from intestinal to liver in miceSemantic proximity Read

DPP4 inhibition affects metabolism and inflammation associated pathways in hiPSC-derived steatotic HLCsSemantic proximity Read

Inhibiting DPP4 activity protects hiPSC-derived steatotic HLCs by supporting fatty acid and purine metabolism and dampening inflammationSemantic proximity Read

PPARα-ERRα crosstalk mitigates metabolic dysfunction-associated steatotic liver disease progressionSemantic proximity Read

Bridging the Gut and Liver: Multi-biotics modulate microbiota composition and corroborate transcriptomic improvements in MASLDSemantic proximity Read

The Role of TM6SF2 in Non-Alcoholic Fatty Liver Disease: From Mechanisms To Therapeutic StrategySemantic proximity Read

Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitisSemantic proximity Read

LncRNA MIR22HG/microRNA-9-3p/IGF1 in nonalcoholic steatohepatitis, the ceRNA network increases fibrosis by inhibiting autophagy and promoting pyroptosisSemantic proximity Read

In vivo anti-FAP CAR T therapy reduces fibrosis and restores liver homeostasis in metabolic dysfunction-associated steatohepatitisSemantic proximity Read