Article

The interplay of TGF-β1 and cholesterol orchestrating hepatocyte cell fate, EMT, and signals for HSC activation

2023-08-15

Abstract excerpt

<h4>Background and Aims: </h4> Transforming growth factor-β1 (TGF-β1) plays important roles in chronic liver diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD). MASLD involves various biological processes including dysfunctional cholesterol metabolism and contributes to progression to metabolic dysfunction-associated steatohepatitis (MASH) and hepatocellular carcinoma (HCC). Howev...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 483a4ae2-b8ac-56a7-9cff-8cbd8b3b972e
DOI: 10.1101/2023.08.14.552900

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The interplay of TGF-β1 and cholesterol orchestrating hepatocyte cell fate, EMT, and signals for HSC activationDOI 10.1101/2023.08.14.552900Read

The Interplay of TGF-β1 and Cholesterol Orchestrating Hepatocyte Cell Fate, EMT, and Signals for HSC ActivationSemantic proximity Read

Coordinated activation of both TGFβ and BMP canonical pathways regulates autophagy and tissue regeneration in acetaminophen induced liver injurySemantic proximity Read

TGF-β serves as a critical signaling determinant of liver progenitor cell fate and functionSemantic proximity Read

Hepatic loss of AATF attenuates MASH by suppressing AKT–mTORC1 signaling and reprogramming lipid metabolismSemantic proximity Read

<scp>TGF</scp>‐β signalling and liver diseaseSemantic proximity Read

Cholangiocyte RUNX1 Orchestrates Fibrogenic and Inflammatory Signaling to Drive Biliary FibrosisSemantic proximity Read

The dichotomous role of TGF-β in controlling liver cancer cell survival and proliferationSemantic proximity Read

Smad4 restricts injury-provoked biliary proliferation and carcinogenesisSemantic proximity Read

Hepatocyte TEAD1 drives epithelial-stromal remodeling during cholestatic liver injurySemantic proximity Read

Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)Semantic proximity Read

Aramchol attenuates fibrosis in mouse models of biliary fibrosis and blocks the TGFβ-induced fibroinflammatory mediators in cholangiocytesSemantic proximity Read

HSD17B13 Couples Hepatocyte Lipid Metabolism to Stellate Cell Activation via TGFb-1 SignalingSemantic proximity Read