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Article

A dietary ketone ester mitigates histological outcomes of NAFLD and markers of fibrosis in high-fat diet fed mice.

American journal of physiology. Gastrointestinal and liver physiology - 1 Apr 2021

Moore Mary P, Cunningham Rory P, Davis Rachel A H, Deemer Sarah E, Roberts Brandon M, Plaisance Eric P, Rector R Scott

Abstract excerpt

Nutritional ketosis as a therapeutic tool has been extended to the treatment of metabolic diseases, including obesity, type 2 diabetes, and nonalcoholic fatty liver disease (NAFLD). The purpose of this study was to determine whether dietary administration of the ketone ester (KE) R,S-1,3-butanediol diacetoacetate (BD-AcAc2) attenuates markers of hepatic stellate cell (HSC) activation and hepatic fibrosis in the...

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Source

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Identifiers

PMID: 33501889
DOI: 10.1152/ajpgi.00259.2020
PMCID: PMC8238172

Genes

CCN1
CD163
CD68
COL1A1
MMP9
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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