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A gut microbial metabolite of linoleic acid ameliorates liver fibrosis by inhibiting TGF-β signaling in hepatic stellate cells

2023-09-19

Abstract excerpt

The antidiabetic drug pioglitazone ameliorates insulin resistance by activating the transcription factor PPARγ. In addition to its blood glucose–lowering action, pioglitazone exerts pleiotropic effects including amelioration of nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH). The mechanism by which pioglitazone achieves this latter effect has remained unclear, however. We here show tha...

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Literature Corpus work
bdb3a567-4848-5e91-b64d-66028fd094b0
DOI
10.21203/rs.3.rs-3323332/v1
Open publication

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A gut microbial metabolite of linoleic acid ameliorates liver fibrosis by inhibiting TGF-β signaling in hepatic stellate cellsDOI 10.21203/rs.3.rs-3323332/v1
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