Article

Allele-specific collateral and fitness effects determine the dynamics of fluoroquinolone-resistance evolution

2020-10-19

Abstract excerpt

Collateral sensitivity (CS), which arises when resistance to one antibiotic increases sensitivity towards other antibiotics, offers novel treatment opportunities to constrain or reverse the evolution of antibiotic-resistance. The applicability of CS-informed treatments remains uncertain, in part because we lack an understanding of the generality of CS effects for different resistance mutations, singly or in combin...

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Identifiers and source

Literature Corpus work: 8784e093-fcaf-53be-9c17-5ba6f5807743
DOI: 10.1101/2020.10.19.345058

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