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Article

Design principles of collateral sensitivity-based dosing strategies.

Nature communications - 28 Sept 2021

Aulin Linda B S, Liakopoulos Apostolos, van der Graaf Piet H, Rozen Daniel E, van Hasselt J G Coen

Abstract excerpt

Collateral sensitivity (CS)-based antibiotic treatments, where increased resistance to one antibiotic leads to increased sensitivity to a second antibiotic, may have the potential to limit the emergence of antimicrobial resistance. However, it remains unclear how to best design CS-based treatment schedules. To address this problem, we use mathematical modelling to study the effects of pathogen- and drug-specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34584086
DOI: 10.1038/s41467-021-25927-3
PMCID: PMC8479078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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