Article

Evolutionary trajectories determine the feasibility of collateral sensitivity based antibiotic treatment strategies in critical bacterial pathogens

2025-06-04

Abstract excerpt

The rise of antibiotic resistance among pathogenic bacteria necessitates innovative therapeutic strategies. A promising technique is the use of collateral sensitivity where resistance to one antibiotic increases susceptibility to another. In this study, we explored the clinical relevance of collateral sensitivity through experimental evolution and genetic engineering in six critical bacterial pathogens using 23 di...

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Literature Corpus work: e030e6c6-9145-5f5d-9057-2f0d4c7d8c6a
DOI: 10.1101/2025.06.03.657621

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