Article
Allele-specific collateral and fitness effects determine the dynamics of fluoroquinolone resistance evolution.
Proceedings of the National Academy of Sciences of the United States of America - 3 May 2022
Liakopoulos Apostolos, Aulin Linda B S, Buffoni Matteo, Fragkiskou Efthymia, van Hasselt J G C, Rozen Daniel E
Abstract excerpt
Collateral sensitivity (CS), which arises when resistance to one antibiotic increases sensitivity toward other antibiotics, offers treatment opportunities to constrain or reverse the evolution of antibiotic resistance. The applicability of CS-informed treatments remains uncertain, in part because we lack an understanding of the generality of CS effects for different resistance mutations, singly or in combination....
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