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Article

The population genetics of collateral resistance and sensitivity.

eLife - 10 Dec 2021

Ardell Sarah M, Kryazhimskiy Sergey

Abstract excerpt

Resistance mutations against one drug can elicit collateral sensitivity against other drugs. Multi-drug treatments exploiting such trade-offs can help slow down the evolution of resistance. However, if mutations with diverse collateral effects are available, a treated population may evolve either collateral sensitivity or collateral resistance. How to design treatments robust to such uncertainty is unclear. We...

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Identifiers

PMID: 34889185
DOI: 10.7554/eLife.73250
PMCID: PMC8765753

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