Article

Lipid Accumulation Induced by APOE4 Impairs Microglial Surveillance of Neuronal-Network Activity

2022-03-21

Abstract excerpt

<h4>Summary</h4> Apolipoprotein E4 (APOE4) is the greatest known genetic risk factor for developing late- onset Alzheimer’s disease and its expression in microglia is associated with pro- inflammatory states. How the interaction of APOE4 microglia with neurons differs from microglia expressing the disease-neutral allele APOE3 is currently unknown. Here, we employ CRISPR-edited induced pluripotent stem cells (iPSC...

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Literature Corpus work: f650de91-d789-5079-a058-f82eaec182ef
DOI: 10.1101/2022.03.21.484146

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