Article

TREM2 expression level is critical for microglial state, metabolic capacity and efficacy of TREM2 agonism

2024-07-22

Abstract excerpt

Triggering receptor expressed on myeloid cells 2 (TREM2) is a central regulator of microglial activity and sequence variants are major risk factors for late onset Alzheimer’s disease (LOAD). To better understand the molecular and functional changes associated with TREM2 signalling, we generated a TREM2 reporter mouse model and observed a gradual upregulation of reporter expression with increasing plaque proximity....

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Literature Corpus work: 870d5dc9-2d31-5206-ba2a-00b1213e37fa
DOI: 10.1101/2024.07.18.604115

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