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<i>Trem2</i> R47H mutation shows mild, but functionally divergent alterations in microglial phenotypes compared to <i>Trem2</i> deficiency in aged <i> App <sup>NL-F</sup> </i> knock-in mice

2026-05-21

Abstract excerpt

The TREM2 R47H variant increases the risk of Alzheimer’s disease (AD), yet its functional impact in aged mouse models remains incompletely understood. We generated a humanized Trem2 R47H knock-in (KI) line on the App NL-F background and compared it with a Trem2 knockout (KO) line to assess the degree of TREM2 functional impairment. Accumulation of amyloid β 42 and formation of dystrophic neurites were increase...

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Literature Corpus work
2218e3b1-de47-504b-a5e5-ae054b16fa00
DOI
10.64898/2026.05.18.724708
Open publication

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<i>Trem2</i> R47H mutation shows mild, but functionally divergent alterations in microglial phenotypes compared to <i>Trem2</i> deficiency in aged <i> App <sup>NL-F</sup> </i> knock-in miceDOI 10.64898/2026.05.18.724708
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