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Article

Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions.

Human molecular genetics - 25 Nov 2020

Liu Wenfei, Taso Orjona, Wang Rui, Bayram Sevinc, Graham Andrew C, Garcia-Reitboeck Pablo, Mallach Anna, Andrews William D, Piers Thomas M, Botia Juan A, Pocock Jennifer M, Cummings Damian M, Hardy John, Edwards Frances A, Salih Dervis A

Abstract excerpt

Genome-wide association studies have reported that, amongst other microglial genes, variants in TREM2 can profoundly increase the incidence of developing Alzheimer's disease (AD). We have investigated the role of TREM2 in primary microglial cultures from wild type mice by using siRNA to decrease Trem2 expression, and in parallel from knock-in mice heterozygous or homozygous for the Trem2 R47H AD risk variant. The...

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Identifiers

PMID: 32959884
DOI: 10.1093/hmg/ddaa209
PMCID: PMC7689298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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