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Article

Investigation of pathology, expression and proteomic profiles in human TREM2 variant postmortem brains with and without Alzheimer's disease.

Brain pathology (Zurich, Switzerland) - 1 Jul 2020

Toomey Christina E, Heywood Wendy, Benson Bridget C, Packham Georgia, Mills Kevin, Lashley Tammaryn

Abstract excerpt

Triggering receptor expressed on myeloid cells 2 TREM2 was identified as a risk factor for late onset Alzheimer's disease (AD). Here we compared TREM2 cases with a variant (TREM2+ ) and cases without a TREM2 variant (TREM2- ), considering pathological burden, inflammatory response and altered canonical pathways and biochemical functions between the cohorts. We hypothesised that TREM2+ cases would have a loss of...

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Identifiers

PMID: 32267026
DOI: 10.1111/bpa.12842
PMCID: PMC8018003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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