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Article

Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Apr 2017

Song Wilbur, Hooli Basavaraj, Mullin Kristina, Jin Sheng Chih, Cella Marina, Ulland Tyler K, Wang Yaming, Tanzi Rudolph E, Colonna Marco

Abstract excerpt

INTRODUCTION: TREM2 is a lipid-sensing activating receptor on microglia known to be important for Alzheimer's disease (AD), but whether it plays a beneficial or detrimental role in disease pathogenesis is controversial. METHODS: We analyzed AD risk of TREM2 variants in the NIMH AD Genetics Initiative Study and AD Sequencing Project. We compared each variant's risk and functional impact by a reporter assay....

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Identifiers

PMID: 27520774
DOI: 10.1016/j.jalz.2016.07.004
PMCID: PMC5299056

Genes

TREM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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