Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.

doi:10.1038/s41467-020-19227-5

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Article

Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease.

Nature communications - 23 Oct 2020

McQuade Amanda, Kang You Jung, Hasselmann Jonathan, Jairaman Amit, Sotelo Alexandra, Coburn Morgan, Shabestari Sepideh Kiani, Chadarevian Jean Paul, Fote Gianna, Tu Christina H, Danhash Emma, Silva Jorge, Martinez Eric, Cotman Carl, Prieto G Aleph, Thompson Leslie M, Steffan Joan S, Smith Ian, Davtyan Hayk, Cahalan Michael, Cho Hansang, Blurton-Jones Mathew

Abstract excerpt

The discovery of TREM2 as a myeloid-specific Alzheimer's disease (AD) risk gene has accelerated research into the role of microglia in AD. While TREM2 mouse models have provided critical insight, the normal and disease-associated functions of TREM2 in human microglia remain unclear. To examine this question, we profile microglia differentiated from isogenic, CRISPR-modified TREM2-knockout induced pluripotent stem...

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PMID: 33097708
DOI: 10.1038/s41467-020-19227-5
PMCID: PMC7584603

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