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Article

A large scale multivariate parallel ICA method reveals novel imaging-genetic relationships for Alzheimer's disease in the ADNI cohort.

NeuroImage - 15 Apr 2012

Meda Shashwath A, Narayanan Balaji, Liu Jingyu, Perrone-Bizzozero Nora I, Stevens Michael C, Calhoun Vince D, Glahn David C, Shen Li, Risacher Shannon L, Saykin Andrew J, Pearlson Godfrey D

Abstract excerpt

The underlying genetic etiology of late onset Alzheimer's disease (LOAD) remains largely unknown, likely due to its polygenic architecture and a lack of sophisticated analytic methods to evaluate complex genotype-phenotype models. The aim of the current study was to overcome these limitations in a bi-multivariate fashion by linking intermediate magnetic resonance imaging (MRI) phenotypes with a genome-wide sample...

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PMID: 22245343
DOI: 10.1016/j.neuroimage.2011.12.076
PMCID: PMC3312985

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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