Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterogeneous effects of genetic risk for Alzheimer's disease on the phenome.

Translational psychiatry - 23 Jul 2021

Wu Hei Man, Goate Alison M, O'Reilly Paul F

Abstract excerpt

Here we report how four major forms of Alzheimer's disease (AD) genetic risk-APOE-ε4, APOE-ε2, polygenic risk and familial risk-are associated with 273 traits in ~500,000 individuals in the UK Biobank. The traits cover blood biochemistry and cell traits, metabolic and general health, psychosocial health, and cognitive function. The difference in the profile of traits associated with the different forms of AD risk...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Apolipoproteins E
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multifactorial Inheritance

Share to Phenotype

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 34301914
DOI: 10.1038/s41398-021-01518-0
PMCID: PMC8302633

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterogeneous effects of genetic risk for Alzheimer's disease on the phenome.PMID 34301914Read ↗

Genetic risk for Alzheimer’s disease, and differential trajectories in circulating blood biomarkers in UK Biobank (n=17,817)Semantic proximity Read ↗

Biobank-wide association scan identifies risk factors for late-onset Alzheimer’s disease and endophenotypesSemantic proximity Read ↗

Biobank-wide association scan identifies risk factors for late-onset Alzheimer's disease and endophenotypes.Semantic proximity Read ↗

Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank.Semantic proximity Read ↗

Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimer’s disease riskSemantic proximity Read ↗

Alzheimer's Disease Susceptibility Gene Apolipoprotein E (APOE) and Blood Biomarkers in UK Biobank (N = 395,769).Semantic proximity Read ↗

Genetic risk for Alzheimer’s disease influences neuropathology and cognition via multiple biological pathwaysSemantic proximity Read ↗

A non- <i>APOE</i> Polygenic score for Alzheimer’s disease and <i>APOE-ε4</i> have independent associations with dementia in the Health and Retirement StudySemantic proximity Read ↗

The causes and consequences of Alzheimer's disease: phenome-wide evidence from Mendelian randomization.Semantic proximity Read ↗

Alzheimer’s disease susceptibility gene apolipoprotein e (<i>APOE</i>) and blood biomarkers in UK Biobank (N=395,769)Semantic proximity Read ↗

Age-dependent effect of APOE and polygenic component on Alzheimer's diseaseSemantic proximity Read ↗

Genetic versus Modifiable Risk: Predicting Dementia, Cognition, and Brain Structure in the UK BiobankSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.