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Article

Polygenic Risk Scores in Alzheimer's Disease Genetics: Methodology, Applications, Inclusion, and Diversity.

Journal of Alzheimer's disease : JAD - 1 Jan 2022

Clark Kaylyn, Leung Yuk Yee, Lee Wan-Ping, Voight Benjamin, Wang Li-San

Abstract excerpt

The success of genome-wide association studies (GWAS) completed in the last 15 years has reinforced a key fact: polygenic architecture makes a substantial contribution to variation of susceptibility to complex disease, including Alzheimer's disease. One straight-forward way to capture this architecture and predict which individuals in a population are most at risk is to calculate a polygenic risk score (PRS)....

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Alzheimer Disease
Genetic Predisposition to Disease
Genome-Wide Association Study
Multifactorial Inheritance
Risk Factors

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PMID: 35848019
DOI: 10.3233/JAD-220025
PMCID: PMC9484091

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