Article

Epistatic Features and Machine Learning Improve Alzheimer’s Risk Prediction Over Polygenic Risk Scores

2023-02-11

Abstract excerpt

<h4>Background</h4> Polygenic risk scores (PRS) are linear combinations of genetic markers weighted by effect size that are commonly used to predict disease risk. For complex heritable diseases such as late onset Alzheimer’s disease (LOAD), PRS models fail to capture much of the heritability. Additionally, PRS models are highly dependent on the population structure of data on which effect sizes are assessed, and h...

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Literature Corpus work: 6667e7a9-ee5a-56de-aa6b-9b95654d98f5
DOI: 10.1101/2023.02.10.23285766

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