Article

TAD-like single-cell domain structures exist on both active and inactive X chromosomes and persist under epigenetic perturbations

2021-05-13

Abstract excerpt

<h4>Background</h4> Topologically associating domains (TADs) are important building blocks of three-dimensional genome architectures. The formation of TADs was shown to depend on cohesin in a loop-extrusion mechanism. Recently, advances in an image-based spatial genomics technique known as chromatin tracing led to the discovery of cohesin-independent TAD-like structures, also known as single-cell domains — highly...

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Literature Corpus work: d6fa092b-72b0-5d4d-aadf-f6c8e565cfab
DOI: 10.1101/2021.05.12.443887

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