Article

Cohesin-dependent and independent mechanisms support chromosomal contacts between promoters and enhancers

2020-02-11

Abstract excerpt

It is currently assumed that 3D chromosomal organisation plays a central role in transcriptional control. However, recent evidence shows that steady-state transcription of only a minority of genes is affected by depletion of architectural proteins such as cohesin and CTCF. Here, we have used Capture Hi-C to interrogate the dynamics of chromosomal contacts of all human gene promoters upon rapid architectural protei...

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Literature Corpus work: 386064f9-5dbc-540e-9a01-546f699468c5
DOI: 10.1101/2020.02.10.941989

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