Article

An H4K20me3-CTCF switch at stable TAD boundaries enforces reversible cell state transitions

2026-01-30

Abstract excerpt

<h4>Summary</h4> Reversible transitions between proliferative and quiescent cell states involve widespread gene expression changes despite stable topologically associating domain (TAD) positioning. We report a reciprocal antagonism between TAD boundary element CTCF and histone modification H4K20me3 as a central mechanism governing the proliferation-quiescence transition. Genome-wide studies and functional perturb...

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Literature Corpus work: ed634d5d-8be9-52a4-a523-e09b3812e075
DOI: 10.64898/2026.01.29.702647

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