Article

Substrate scope and catalytic mechanism of α, β-epoxyketone synthase EpnF illuminated by <i>in situ</i> esterase-mediated deprotection

2025-12-25

Abstract excerpt

<h4>ABSTRACT</h4> α, β-Epoxyketones are an important class of bacterial natural products with wide-ranging potential applications in oncology, immunology, and infectious disease. Their clinical potential derives from the α, β-epoxyketone pharmacophore, which covalently modifies the N -terminal catalytic threonine residue of proteasome β-subunits with high selectivity. Although a synthetic α, β-epoxyketone (Carfi...

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Literature Corpus work: 86d95c65-517a-575c-ac52-ac347c7cd419
DOI: 10.64898/2025.12.23.696313

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Substrate scope and catalytic mechanism of α, β-epoxyketone synthase EpnF illuminated by <i>in situ</i> esterase-mediated deprotectionDOI 10.64898/2025.12.23.696313Read

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