Article

SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species

2021-09-15

Abstract excerpt

<h4>ABSTRACT</h4> Hundreds of cytotoxic natural or synthetic lipidic compounds contain chiral alkynylcarbinol motifs, but the mechanism of action of those potential therapeutic agents remains unknown. Using a genetic screen in haploid human cells, we discovered that the enantiospecific cytotoxicity of numerous terminal alkynylcarbinols, including the highly cytotoxic dialkynylcarbinols, involves a bioactivation b...

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Literature Corpus work: 9f810541-2e4b-5442-8f63-c6611a250cb2
DOI: 10.1101/2021.09.15.460423

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