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Article

Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides.

Molecular bioSystems - 1 Jul 2007

Evans Michael J, Morris Garrett M, Wu Jane, Olson Arthur J, Sorensen Erik J, Cravatt Benjamin F

Abstract excerpt

We recently reported the pharmacological screening of a natural products-inspired library of spiroepoxide probes, resulting in the discovery of an agent MJE3 that displayed anti-proliferative effects in human breast cancer cells. MJE3 was found to covalently inactivate phosphoglycerate mutase-1 (PGAM1), a glycolytic enzyme with postulated roles in cancer cell metabolism and proliferation. Considering that MJE3 is...

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Identifiers

PMID: 17579775
DOI: 10.1039/b705113a

Genes

PGAM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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