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Article

Hijacking a hydroxyethyl unit from a central metabolic ketose into a nonribosomal peptide assembly line.

Proceedings of the National Academy of Sciences of the United States of America - 29 May 2012

Peng Chao, Pu Jin-Yue, Song Li-Qiang, Jian Xiao-Hong, Tang Man-Cheng, Tang Gong-Li

Abstract excerpt

Nonribosomal peptide synthetases (NRPSs) usually catalyze the biosynthesis of peptide natural products by sequential selection, activation, and condensation of amino acid precursors. It was reported that some fatty acids, α-ketoacids, and α-hydroxyacids originating from amino acid metabolism as well as polyketide-derived units can also be used by NRPS assembly lines as an alternative to amino acids. Ecteinascidin...

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Identifiers

PMID: 22586110
DOI: 10.1073/pnas.1204232109
PMCID: PMC3365175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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