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Article

Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade.

Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2017

Zhang Zhuan, Gong Yu-Kang, Zhou Qiang, Hu Yu, Ma Hong-Min, Chen Yong-Sheng, Igarashi Yasuhiro, Pan Lifeng, Tang Gong-Li

Abstract excerpt

Ranking among the most effective anticancer drugs, anthracyclines represent an important family of aromatic polyketides generated by type II polyketide synthases (PKSs). After formation of polyketide cores, the post-PKS tailoring modifications endow the scaffold with various structural diversities and biological activities. Here we demonstrate an unprecedented four-enzyme-participated hydroxyl regioisomerization...

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Identifiers

PMID: 28137838
DOI: 10.1073/pnas.1610097114
PMCID: PMC5321016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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