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Article

Structural and Functional Analyses of a Spiro-Carbon-Forming, Highly Promiscuous Epoxidase from Fungal Natural Product Biosynthesis.

Biochemistry - 29 Dec 2020

Matsushita Takuma, Kishimoto Shinji, Hara Kodai, Hashimoto Hiroshi, Watanabe Kenji

Abstract excerpt

Biosynthesis of fungal nonribosomal peptides frequently involves redox enzymes such as flavin-containing monooxygenase (FMO) to introduce complexity into the core chemical structure. One such example is the formation of spiro-carbons catalyzed by various oxidases. Because many chemically complex spiro-carbon-bearing natural products exhibit useful biological activities, understanding the mechanism of spiro-carbon...

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PMID: 33332106
DOI: 10.1021/acs.biochem.0c00896

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