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Article

Characterization and structural analysis of a versatile aromatic prenyltransferase for imidazole-containing diketopiperazines.

Nature communications - 2 Jan 2025

Wang Wenxue, Wang Peng, Ma Chuanteng, Li Kang, Wang Zian, Liu Yuting, Wang Lu, Zhang Guojian, Che Qian, Zhu Tianjiao, Zhang Yuzhong, Li Dehai

Abstract excerpt

Prenylation modifications of natural products play essential roles in chemical diversity and bioactivities, but imidazole modification prenyltransferases are not well investigated. Here, we discover a dimethylallyl tryptophan synthase family prenyltransferase, AuraA, that catalyzes the rare dimethylallylation on the imidazole moiety in the biosynthesis of aurantiamine. Biochemical assays validate that AuraA could...

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Bacterial Proteins
Cryoelectron Microscopy
Imidazoles
Models, Molecular
Mutation

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PMID: 39747040
DOI: 10.1038/s41467-024-55537-8
PMCID: PMC11696170

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