Article

<i>In vivo</i> –Active Soluble Epoxide Hydrolase–targeting PROTACs with Improved Potency and Stability

2024-07-24

Abstract excerpt

<h4>ABSTRACT</h4> Soluble epoxide hydrolase (sEH) is a bifunctional enzyme involved in fatty acid metabolism and promising drug target. We previously reported first-generation sEH proteolysis–targeting chimeras (PROTACs) with limited degradation potency and low aqueous and metabolic stability. Herein, we report the development of next-generation sEH PROTAC molecules with improved stability and degradation potency...

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Literature Corpus work: e0798967-0bb2-5d28-bb9d-36fe460e8a68
DOI: 10.1101/2024.07.23.604814

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