Article

Dedifferentiation-Driven Oncogenic Stemness Promotes Tumor-Sustaining Adaptability in the Intestinal Epithelium

2025-10-23

Abstract excerpt

<h4>ABSTRACT</h4> Intestinal tumorigenesis can occur via two distinct routes: bottom-up tumorigenesis occurs from mutations sustained in the Lgr5⁺ stem cells, whereas top-down tumorigenesis is driven by dedifferentiation of epithelial cells near the intestinal lumen. While sporadic human colon adenomas exhibit features of top-down tumorigenesis, their biological determinants remain elusive. Here, using a Smad4...

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Literature Corpus work: 86a649fa-04d8-5ccf-80d0-e16a23bf9bc5
DOI: 10.1101/2025.10.22.683922

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