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The nutritional environment determines which and how intestinal stem cells contribute to homeostasis and tumorigenesis

4 Jun 2019

Abstract excerpt

Sporadic colon cancer accounts for approximately 80% of colorectal cancer (CRC) with high incidence in Western societies strongly linked to long-term dietary patterns. A unique mouse model for sporadic CRC results from feeding a purified rodent Western-style diet (NWD1) recapitulating intake for the mouse of common nutrient risk factors each at its level consumed in higher risk Western populations. This causes...

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PMID: 31169292
DOI: 10.1093/carcin/bgz106

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