Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SMAD4 Suppresses WNT-Driven Dedifferentiation and Oncogenesis in the Differentiated Gut Epithelium

9 Jul 2018

Abstract excerpt

Abstract The cell of origin of colon cancer is typically thought to be the resident somatic stem cells, which are immortal and escape the continual cellular turnover characteristic of the intestinal epithelium. However, recent studies have identified certain conditions in which differentiated cells can acquire stem-like properties and give rise to tumors. Defining the origins of tumors will inform cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Digestive system and related health
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29986996
DOI: 10.1158/0008-5472.can-18-0043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SMAD4 Suppresses WNT-Driven Dedifferentiation and Oncogenesis in the Differentiated Gut EpitheliumPMID 29986996Read ↗

Dedifferentiation-Driven Oncogenic Stemness Promotes Tumor-Sustaining Adaptability in the Intestinal EpitheliumSemantic proximity Read ↗

Identification, isolation and characterization of human LGR5-positive colon adenoma cellsSemantic proximity Read ↗

Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colonSemantic proximity Read ↗

Identification, Isolation, and Characterization of Human LGR5-positive Colon Adenoma CellsSemantic proximity Read ↗

Therapeutic implications of colon cancer stem cellsSemantic proximity Read ↗

Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomasSemantic proximity Read ↗

Wnt signaling in adult intestinal stem cells and cancerSemantic proximity Read ↗

Disruption of the crypt niche promotes outgrowth of mutated colorectal tumor stem cellsSemantic proximity Read ↗

Origin, development and therapy of colorectal cancer from the perspective of a biologist and an oncologistSemantic proximity Read ↗

Wnt and BMP signals control intestinal adenoma cell fates.Semantic proximity Read ↗

Colonic epithelial adaptation to EGFR-independent growth induces chromosomal instability and is accelerated by prior injury.Semantic proximity Read ↗

Signaling in colon cancer stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.