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Article

Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas

17 Nov 2021

Abstract excerpt

expression suppresses intestinal tumorigenesis by restricting adenoma cell dedifferentiation to a crypt-progenitor phenotype and by reducing the formation of cancer stem cell niches.

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PMID: 34788095
DOI: 10.1126/sciadv.abj0512

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