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Identification, isolation and characterization of human LGR5-positive colon adenoma cells

21 Feb 2018

Abstract excerpt

The intestine is maintained by stem cells located at the base of crypts and distinguished by the expression of LGR5. Genetically engineered mouse models have provided a wealth of information about intestinal stem cells, whereas less is known about human intestinal stem cells owing to difficulty detecting and isolating these cells. We established an organoid repository from patient-derived adenomas,...

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PMID: 29467240
DOI: 10.1242/dev.153049

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