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Article

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia

1 Aug 2022

Abstract excerpt

Intestinal homeostasis is underpinned by LGR5+ve crypt-base columnar stem cells (CBCs), but following injury, dedifferentiation results in the emergence of LGR5-ve regenerative stem cell populations (RSCs), characterized by fetal transcriptional profiles. Neoplasia hijacks regenerative signaling, so we assessed the distribution of CBCs and RSCs in mouse and human intestinal tumors. Using combined...

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PMID: 35931031
DOI: 10.1016/j.stem.2022.07.008

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