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Article

Co-targeting Deregulated WNT and MAPK Signaling Pathways Limits Phenotypic Reprogramming of Intestinal Stem Cell Progeny in KRAS-Hyperactivated Colorectal Cancer.

Cancer research - 15 Sept 2026

Palladino Silvia, Yaeger Rona

Abstract excerpt

In their recent article, Moore and colleagues demonstrate that, upon KRAS hyperactivation, colorectal cancer growth is driven by a reprogramming of Lgr5+ intestinal stem cell (ISC) progeny towards the acquisition of a regenerative phenotype. They find that this phenotype is regulated by a balance between WNT-related ISCs and MAPK-related regenerative and proliferative transcriptional programs. By targeting both...

Read the complete abstract on PubMed

Topics

Colorectal Neoplasms
Humans
Animals
Stem Cells
Wnt Signaling Pathway
Proto-Oncogene Proteins p21(ras)

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

MAP Kinase Signaling System

Mice

Phenotype

Intestines

Source

Identifiers

PMID: 42517858
DOI: 10.1158/0008-5472.CAN-26-3173

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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