Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colon

21 Oct 2013

Abstract excerpt

BACKGROUND: Colon cancer stem cells are shown to be the self-renewing cells within a tumor that give rise to all lineages of more differentiated tumor cells. In this respect they are remarkably similar to their non-malignant counterparts that orchestrate the intestinal lining. This suggests that, despite the numerous genetic aberrations and morphological changes that have occurred during cancer initiation and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Liver physiology and pathology
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24144042
DOI: 10.1186/1476-4598-12-126

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of stem cell self-renewal and differentiation by Wnt and Notch are conserved throughout the adenoma-carcinoma sequence in the colonPMID 24144042Read ↗

Self-renewal and cancer of the gut: two sides of a coin.Semantic proximity Read ↗

Wnt and BMP signals control intestinal adenoma cell fates.Semantic proximity Read ↗

Wnt signaling in adult intestinal stem cells and cancerSemantic proximity Read ↗

Dedifferentiation-Driven Oncogenic Stemness Promotes Tumor-Sustaining Adaptability in the Intestinal EpitheliumSemantic proximity Read ↗

Wnt signaling in the intestinal epithelium: from endoderm to cancer.Semantic proximity Read ↗

SMAD4 Suppresses WNT-Driven Dedifferentiation and Oncogenesis in the Differentiated Gut EpitheliumSemantic proximity Read ↗

A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts.Semantic proximity Read ↗

Canonical Wnt signals combined with suppressed TGFβ/BMP pathways promote renewal of the native human colonic epitheliumSemantic proximity Read ↗

NOTCH Signaling Is Required for Formation and Self-Renewal of Tumor-Initiating Cells and for Repression of Secretory Cell Differentiation in Colon CancerSemantic proximity Read ↗

Identification, Isolation, and Characterization of Human LGR5-positive Colon Adenoma CellsSemantic proximity Read ↗

Identification, isolation and characterization of human LGR5-positive colon adenoma cellsSemantic proximity Read ↗

Wnt signaling in cancer stem cells and colon cancer metastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.