Article

Ferroptosis regulates hemolysis in stored murine and human red blood cells

2024-06-11

Abstract excerpt

<h4>Summary</h4> Red blood cell (RBC) metabolism regulates hemolysis during aging in vivo and in the blood bank. Here, we leveraged a diversity outbred mouse population to map the genetic drivers of fresh/stored RBC metabolism and extravascular hemolysis upon storage and transfusion in 350 mice. We identify the ferrireductase Steap3 as a critical regulator of a ferroptosis-like process of lipid peroxidation. Stea...

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Literature Corpus work: 85bc4a54-4abc-5126-9140-eca68f931773
DOI: 10.1101/2024.06.11.598512

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