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Ferroptosis regulates hemolysis in stored murine and human red blood cells

14 Nov 2024

Abstract excerpt

ABSTRACT: Red blood cell (RBC) metabolism regulates hemolysis during aging in vivo and in the blood bank. However, the genetic underpinnings of RBC metabolic heterogeneity and extravascular hemolysis at population scale are incompletely understood. On the basis of the breeding of 8 founder strains with extreme genetic diversity, the Jackson Laboratory diversity outbred population can capture the impact of genetic...

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PMID: 39541586
DOI: 10.1182/blood.2024026109

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