Article

Transcriptomic atlas reveals inflammation and complement as pathogenic factors in hemolysis-induced tissue damage

2025-10-14

Abstract excerpt

<title>Abstract</title> <p>Intravascular hemolysis contributes to sickle cell disease (SCD) by releasing danger signals like hemoglobin and heme, which trigger inflammation and oxidative stress. Yet, the exact mechanisms behind organ damage remain unclear. Using bulk RNA sequencing in a phenylhydrazine-induced hemolysis model in mice, we mapped transcriptional changes across the spleen, liver, lung, and kidney. W...

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Literature Corpus work: fbd8f77c-af22-561b-afb8-aaf1804119d6
DOI: 10.21203/rs.3.rs-7781781/v1

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