Genetic regulation of carnitine metabolism controls lipid damage repair and aging RBC hemolysis in vivo and in vitro.

doi:10.1182/blood.2024023983

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Genetic regulation of carnitine metabolism controls lipid damage repair and aging RBC hemolysis in vivo and in vitro.

Blood - 13 Jun 2024

Nemkov Travis, Key Alicia, Stephenson Daniel, Earley Eric J, Keele Gregory R, Hay Ariel, Amireault Pascal, Casimir Madeleine, Dussiot Michaël, Dzieciatkowska Monika, Reisz Julie A, Deng Xutao, Stone Mars, Kleinman Steve, Spitalnik Steven L, Hansen Kirk C, Norris Philip J, Churchill Gary A, Busch Michael P, Roubinian Nareg, Page Grier P, Zimring James C, Arduini Arduino, D'Alessandro Angelo

Abstract excerpt

ABSTRACT: Recent large-scale multiomics studies suggest that genetic factors influence the chemical individuality of donated blood. To examine this concept, we performed metabolomics analyses of 643 blood units from volunteers who donated units of packed red blood cells (RBCs) on 2 separate occasions. These analyses identified carnitine metabolism as the most reproducible pathway across multiple donations from...

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PMID: 38513237
DOI: 10.1182/blood.2024023983
PMCID: PMC11208298

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