Article

Heme-stress activated NRF2 signaling skews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophages

2021-07-29

Abstract excerpt

<h4>ABSTRACT</h4> Heme is an erythrocyte-derived toxin that drives disease progression in hemolytic anemias, such as sickle cell disease. During hemolysis, specialized bone marrow-derived macrophages with a high heme-metabolism capacity orchestrate disease adaptation by removing damaged erythrocytes and heme-protein complexes from the blood and supporting iron recycling for erythropoiesis. Since chronic heme-stre...

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Literature Corpus work: bf9ab125-06fb-596b-9e39-cb41473a244e
DOI: 10.1101/2021.07.29.454342

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