Article

The interactome of the N-terminus of band 3 regulates red blood cell metabolism and storage quality

2020-11-30

Abstract excerpt

Band 3 (anion exchanger 1 - AE1) is the most abundant membrane protein in red blood cells (RBCs), the most abundant cell in the human body. A compelling model, based on indirect evidence, posits that - at high oxygen saturation - the N-term cytosolic domain of AE1 binds to and inhibits glycolytic enzymes, thus diverting metabolic fluxes to the pentose phosphate pathway to generate reducing equivalents. Dysfunction...

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Literature Corpus work: 78a13688-6919-54ee-b040-4ef5596c8aa4
DOI: 10.1101/2020.11.30.404756

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