Article

Genetic architecture of the red blood cell proteome in genetically diverse mice reveals central role of hemoglobin beta cysteine redox status in maintaining circulating glutathione pools

2025-03-04

Abstract excerpt

<h4>ABSTRACT</h4> Red blood cells (RBCs) transport oxygen but accumulate oxidative damage over time, reducing function in vivo and during storage—critical for transfusions. To explore genetic influences on RBC resilience, we profiled proteins, metabolites, and lipids from fresh and stored RBCs obtained from 350 genetically diverse mice. Our analysis identified over 6,000 quantitative trait loci (QTL). Compared to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 350b5978-59bc-5b1f-8175-846d89076c6e
DOI: 10.1101/2025.02.27.640676

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic architecture of the red blood cell proteome in genetically diverse mice reveals central role of hemoglobin beta cysteine redox status in maintaining circulating glutathione poolsDOI 10.1101/2025.02.27.640676Read

Ferroptosis regulates hemolysis in stored murine and human red blood cellsSemantic proximity Read

Differences in Steap3 expression are a mechanism of genetic variation of RBC storage and oxidative damage in mice.Semantic proximity Read

Genetic variation of human G6PD impacts Red Blood Cell transfusion efficacySemantic proximity Read

A population-scale Red Blood Cell proteome atlas of 13,000 donors uncovers genetically encoded aging clocks predicting hemolysis, transfusion efficacy, and donor activity a decade laterSemantic proximity Read

Mouse background genetics in biomedical research: The devil's in the details.Semantic proximity Read

Genetic regulation of carnitine metabolism controls lipid damage repair and aging RBC hemolysis in vivo and in vitro.Semantic proximity Read

Classification of the disorders of hemoglobin.Semantic proximity Read

Heat-shock protein-27, -70 and peroxiredoxin-II show molecular chaperone function in sickle red cells: Evidence from transgenic sickle cell mouse model.Semantic proximity Read

Deep Red Blood Cell Proteome Defines the Band 3 N-Terminus Interactome as a Regulator of Hypoxic Adaptation via BLVRB-Dependent <i>S</i> -Nitroso TransferSemantic proximity Read

Metabolic and Proteomic Divergence is Present in Spleens and Livers from Berkeley Sickle Cell Anemia and β-Thalassemia MiceSemantic proximity Read

Proteomic analysis of red blood cells and the potential for the clinic: what have we learned so far?Semantic proximity Read