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Article

Mouse background genetics in biomedical research: The devil's in the details.

Transfusion - 1 Oct 2021

Hay Ariel M, Howie Heather L, Gorham James D, D'Alessandro Angelo, Spitalnik Steven L, Hudson Krystalyn E, Zimring James C

Abstract excerpt

BACKGROUND: Genetically modified mice are used widely to explore mechanisms in most biomedical fields-including transfusion. Concluding that a gene modification is responsible for a phenotypic change assumes no other differences between the gene-modified and wild-type mice besides the targetted gene. STUDY DESIGN AND METHODS: To test the hypothesis that the N-terminus of Band3, which regulates metabolism, affects...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34480352
DOI: 10.1111/trf.16628
PMCID: PMC8627118

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