Article

Genetic variation of human G6PD impacts Red Blood Cell transfusion efficacy

2025-11-22

Abstract excerpt

<h4>Summary</h4> Glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common human enzymopathy, affects 6% of the global population, yet its impact on blood storage and transfusion efficacy remains undefined. We integrated genome–metabolome–proteome analyses of 13,091 blood donors (362 G6PD SNPs), validated in a recalled cohort (n=643), linked donor–recipient databases, humanized mouse models (canonical,...

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Literature Corpus work: 96383465-e16a-5b8a-bed4-0abab25e17dc
DOI: 10.1101/2025.11.21.689741

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